Microbiome Balance for Sensitive Systems & GLP-1 Digestion
Navigating IBS or adapting to GLP-1 therapy can disrupt your gut microbiome, leading to irregularity, bloating, and daily discomfort. Our MD PhD-formulated Advanced Probiotic & Prebiotic is designed to restore balance gently, strictly avoiding the highly fermentable fibers that trigger sensitive stomachs.
Dual-Action Support for Your Gut
For the Low FODMAP Community: Traditional prebiotics (like inulin or chicory root) can trigger severe bloating and trapped gas in people with IBS or SIBO. We use gut-friendly prebiotics paired with clinically studied probiotic strains to support digestion safely.
For GLP-1 Users: Slower gastric emptying often leads to gut stagnation and discomfort. This gentle daily supplement supports steady digestion, regularity, and microbiome health as your body adjusts to new eating patterns.
How to Use: Take 2 capsules daily, preferably with meals, as part of a consistent gut-health routine.
What is in it (from the Supplement Facts label)
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Prebiotic: PreforPro® 15 mg per serving, a bacteriophage blend (LH01 Myoviridae, LL5 Siphoviridae, T4D Myoviridae, LL12 Myoviridae). It is not a fiber, so there is no inulin, chicory root or FOS to ferment.
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Probiotics: 4.4 billion CFU per serving: DE111® Bacillus subtilis, Bacillus coagulans, Lactobacillus acidophilus and Bifidobacterium lactis.
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Serving: 2 vegetable capsules, 30 servings per bottle (60 capsules). Label direction: take 2 capsules daily, preferably with meals.
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Other ingredients: delayed-release capsule (hydroxypropyl methylcellulose, pectin, water), maltodextrin, medium chain triglycerides.
Evidence and quality: what backs this product
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Third-party tested — independent lab verified, made in a cGMP facility.
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FODMAP-conscious formulation — no high-FODMAP fillers such as inulin or chicory root.
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Formulated by Onikepe Adegbola, MD, PhD, a physician-scientist and the founder of Casa de Sante.
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Price: $45.99 (direct from Casa de Sante).
What this product cannot do
The Advanced Probiotic & Prebiotic synbiotic is a dietary supplement, not a medicine. It does not treat, cure or prevent IBS, SIBO, or any disease, it does not replace a low-FODMAP elimination diet or prescribed therapy, and it will not stop symptoms caused by an untreated medical condition. If you have new, severe, or changing GI symptoms, or you are pregnant, nursing, or on prescription medication (including GLP-1 medication), speak to your clinician first.
Frequently asked questions
What is the difference between this and a plain probiotic?
This is a synbiotic: it pairs 4.4 billion CFU of four probiotic strains with PreforPro, a bacteriophage prebiotic that supports beneficial bacteria without adding fermentable fiber. Our plain probiotic (GI Support, $22.99) has no added prebiotic.
Will the prebiotic make me bloated?
The prebiotic is PreforPro, a bacteriophage blend rather than a fiber, so it avoids the highly fermentable fibers (inulin, chicory root, FOS) that most often trigger gas in sensitive guts. Start with the lowest suggested serving and build up.
Is it suitable during the low-FODMAP elimination phase?
It is formulated to be FODMAP-conscious, but during a strict elimination phase introduce any supplement one at a time so you can attribute symptoms correctly.
How many capsules a day?
Two capsules daily, preferably with meals, per the label.
Can I take it with GLP-1 medication?
People on GLP-1s commonly use it for regularity as eating patterns change. Confirm with your prescriber first.
Is it third-party tested?
Yes — independent lab verified, made in a cGMP facility.
Product details and price last verified October 13, 2026 (ingredients checked against the Supplement Facts label).
